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A Predictive Diagnostic Model for IgA Vasculitis Based on a Metabolomic Approach
Background/Purpose: IgA vasculitis is a rare systemic disease that is life-threatening mainly due to digestive or renal involvement. To date, there is no reliable diagnostic marker. The objective was...
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Effect of Avacopan, a Selective C5a Receptor Inhibitor, on Kidney Function in...
Background/Purpose: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is a life- or organ-threatening condition in which patients experience severe inflammation of small blood...
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Efficacy and Safety of Subcutaneous Belimumab (BEL) and Rituximab (RTX)...
Background/Purpose: Disease control remains an unmet need in SLE. The rationale for sequential BEL and RTX therapy in SLE was previously published.1 This study evaluated the efficacy, safety, and...
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Neither Add-on nor Withdrawal of Methotrexate Impacts Efficacy of IL12/23...
Background/Purpose: Methotrexate (MTX) is often used as first-line DMARD-therapy in active psoriatic arthritis (PsA). Randomized clinical trials usually require treatment failure or intolerance of...
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Cardiovascular Risk of Hydroxychloroquine in the Treatment of Rheumatoid...
Background/Purpose: Hydroxychloroquine (HCQ) is a commonly used 1st-line disease-modifying antirheumatic drug (DMARD) for patients with rheumatoid arthritis (RA) in the U.S., while methotrexate (MTX)...
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A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety,...
Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a prevalent and morbid condition leading to premature death in 10% of those affected. The TRAIL1 trial was a...
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A Prediction Model to Distinguish Patients with Multisystem Inflammatory...
Background/Purpose: Multisystem inflammatory syndrome in children (MIS-C) is a rare consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MIS-C shares features with common...
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Association of Limited Health Literacy with Clinical and Patient-Reported...
Background/Purpose: Health literacy (HL) is an important social determinant of health defined as the ability to understand and use health information. Limited HL is associated with worse clinical...
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Depletion of KLRG1+ T Cells in a First-in-human Clinical Trial of ABC008 in...
Background/Purpose: Inclusion body myositis (IBM), a relentlessly progressive autoimmune skeletal muscle disease, has no effective available pharmacological therapy. A prominent feature of IBM on...
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Comparative Safety of Gout “Treat-to-target” and “Usual Care” Treatment...
Background/Purpose: Rheumatology societies recommend serum-urate (SU)-driven treat-to-target (TTT) strategies for the management of gout. However, cardiovascular (CV) safety of urate-lowering therapy...
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