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Depletion of KLRG1+ T Cells in a First-in-human Clinical Trial of ABC008 in...
Background/Purpose: Inclusion body myositis (IBM), a relentlessly progressive autoimmune skeletal muscle disease, has no effective available pharmacological therapy. A prominent feature of IBM on...
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Comparative Safety of Gout “Treat-to-target” and “Usual Care” Treatment...
Background/Purpose: Rheumatology societies recommend serum-urate (SU)-driven treat-to-target (TTT) strategies for the management of gout. However, cardiovascular (CV) safety of urate-lowering therapy...
View ArticleRituximab versus Conventional Therapeutic Strategy for Remission Induction in...
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic ANCA-associated vasculitis.Glucocorticoids, alone or in combination with cyclophosphamide in severe forms,...
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Phase 2 Study Results from a Randomized, Double-blind, Placebo-controlled,...
Background/Purpose: Gout can be effectively managed by inhibiting synthesis of uric acid. Tigulixostat is a novel non-purine selective xanthine oxidase inhibitor which lowers production of uric acid...
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Efficacy of Emapalumab, an Anti-IFNγ Antibody in Patients with Macrophage...
Background/Purpose: MAS is a life-threatening complication of rheumatic diseases, occurring most frequently in sJIA. The mainstay of MAS treatment is high dose GCs; however, GCs do not always provide...
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SARS-CoV-2 Infections Among Vaccinated Individuals with Rheumatic Disease:...
Background/Purpose: While COVID-19 vaccinations are a critical tool to prevent severe infections, poor immunogenicity in immunocompromised people threatens vaccine effectiveness. We analyzed clinical...
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Secukinumab in Giant Cell Arteritis: A Randomized, Parallel-group,...
Background/Purpose: Little is known about glucocorticoid-sparing agents in giant cell arteritis (GCA) except for IL-6 inhibition. Secukinumab (SEC) has shown significant improvements in the signs and...
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COVID-19 Vaccine Antibody Responses in Patients Treated with B-Cell Agents...
Background/Purpose: Optimal COVID-19 vaccine responses are necessary to protect against severe infection. Patients with systemic rheumatic diseases (SRD) are at risk for not mounting adequate immune...
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Humoral and Cellular Immune Responses to a Second Dose of COVID-19 Vaccine...
Background/Purpose: COVID-19 vaccines have robust immunogenicity in the general population. Data on individuals with immune-mediated inflammatory diseases who are taking immunosuppressants remains...
View ArticleCOVID-19 Vaccine in Immunosuppressed Adults with Autoimmune Diseases
Background/Purpose: Immunocompromised conditions and/or a history of autoimmune disease were exclusion criteria of the initial SARS-CoV-2 vaccines clinical trials. We assessed the safety and...
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